Glucotrack’s Continuous Blood Glucose Monitor (CBGM) is a long-term, implantable system that continually measures blood glucose levels with a sensor longevity of 3 years, no on-body wearable component and with minimal calibration. The Glucotrack CBGM is an Investigational Device and is limited by federal (or United States) law to investigational use.

Non-invasive brain-computer interfaces represent a transformative advancement in restoring communication for individuals with severe motor disabilities. Unlike invasive surgical alternatives, these systems offer enhanced accessibility and safety while supporting broader deployment potential. Communication-focused BCIs must effectively convert brain signals into reliable outputs such as spelling and selection without requiring muscle activity. Electroencephalography dominates current applications due to its portability and superior temporal resolution, though alternative modalities are being explored to enhance system robustness. Despite significant progress in BCI technology, challenges persist in translating these systems beyond controlled laboratory environments, highlighting the ongoing need for further development and innovation in this critical field.

Brain-computer interface technologies represent a transformative frontier in treating neuropsychiatric disorders through advanced neural recording and neurostimulation capabilities. These emerging technologies enable direct communication between the brain and external devices, facilitating precise monitoring of neural activity and targeted therapeutic interventions. By leveraging sophisticated recording techniques and stimulation protocols, researchers can address conditions including depression, anxiety, and neurological disorders with unprecedented precision. This approach offers significant advantages over conventional treatment modalities, particularly for patients with treatment-resistant conditions. As the field advances, brain-computer interface applications demonstrate considerable promise in revolutionizing neuropsychiatric care, improving patient outcomes, and expanding therapeutic options for previously intractable neurological and psychiatric conditions.

Recent advances in implantable brain-computer interfaces represent a significant breakthrough in neurorehabilitation, offering promising solutions for patients suffering from paralysis. These sophisticated technologies enable direct communication between the brain and external devices, effectively bypassing damaged neural pathways to restore motor function. The review examines cutting-edge developments in implantable interface design, signal processing algorithms, and clinical applications, highlighting the transformative potential of this emerging field. As researchers continue to refine these systems, implantable brain-computer interfaces demonstrate increasing efficacy in restoring voluntary movement and improving quality of life for individuals with severe motor impairments, marking a pivotal advancement in regenerative neurology.

China's National Medical Products Administration has approved the NEO system, developed by Shanghai-based Neuracle Medical Technology, marking the world's first invasive brain-computer interface cleared for commercial clinical use. The device combines an implanted BCI with an EEG electrode kit and pneumatic robotic glove to restore limited hand movement in quadriplegic patients with cervical spinal cord injuries. Clinical trials involving 36 participants demonstrated improved hand grasping ability across all subjects, with some showing signs of neural remodeling suggesting potential recovery of additional neurological function. The system operates by detecting neural signals associated with movement intent and wirelessly transmitting them to the robotic glove, enabling patients to grasp and release objects. Shanghai has announced three new research centers to accelerate the technology's further development.

CorTec’s Brain Interchange system combines neural signal recording with adaptive stimulation in a closed-loop architecture. Unlike BCIs focused solely on enabling communication through external devices, the system is designed to both interpret brain signals and deliver therapeutic stimulation aimed at restoring motor function.The platform is currently being evaluated in an FDA-approved investigational device exemption (IDE) study at the University of Washington in Seattle. According to the company, this represents the first clinical investigation of a fully implantable, wireless BCI system for stroke rehabilitation in humans.

Elon Musk promised Neuralink would bring superhuman abilities and minds merged with AI. Then he fueled a runaway hype train for his brain implant technology, which ended up with a grisly record for implants in monkeys and some success with human subjects. But for all of the hype, he’s still further away than Mars from his goal. And that’s because his relentless ambition is once again hitting the wall of scientific reality.

L'interface cerveau-ordinateur (BCI) ne relève plus de la science-fiction, mais la course effrénée lancée par Elon Musk avec Neuralink a-t-elle sacrifié la prudence médicale sur l'autel du spectacle technologique ? Alors que les annonces médiatiques fascinent le grand public, la réalité clinique des implants révèle des défis structurels majeurs qui remettent en question la viabilité de l'approche « tout ou rien ». Neuralink a-t-il fait le mauvais pari en misant tout sur une technologie invasive et complexe au détriment de la sécurité et de la scalabilité ? Nous analysons ici les implications techniques, biologiques et éthiques de cette stratégie audacieuse à la lumière des récents résultats cliniques. 

In 1985, Imbrie had woken up in the hospital after a car accident with a broken neck and a doctor telling him he’d never use his hands or legs again. His response was an expletive, he says—and a decision. “I’m not going to allow someone to tell me what I can and can’t do.” With the determination of a head-strong 22-year-old, Imbrie gradually regained the ability to walk and some limited arm movement. Aware of how unusual his recovery was, the Illinois-native wanted to help others in similar situations and began looking for research projects related to spinal cord injuries. For decades, though, he wasn’t the right fit, until in 2020 he was finally accepted into a University of Chicago trial.

In a groundbreaking convergence of neuroscience and robotics, researchers from the Keck School of Medicine of USC, the University of California, Irvine (UCI), and the California Institute of Technology (Caltech) have propelled the ambitious quest to restore walking and sensation in patients with paraplegia forward. Their innovative work harnesses the power of a fully implantable brain-computer interface (BCI) integrated with a wearable robotic exoskeleton, marking a significant leap towards reestablishing natural, bidirectional communication between the brain and limbs once paralyzed.

California-based startup Sabi is developing a noninvasive brain-computer interface (BCI) that converts a person’s internal speech into text displayed on a computer.Unlike companies such as Neuralink that focus on surgically implanted devices, Sabi aims to make this technology accessible to the general public through wearable devices like a beanie and a baseball cap.The device relies on electroencephalography (EEG) to detect brain activity, and Sabi plans to use 70,000 to 100,000 miniature sensors to improve signal accuracy. The initial typing speed is projected at around 30 words per minute, with improvements expected as users become accustomed to the device.To handle the variability in individual thought patterns, Sabi is creating a large-scale AI model, called a brain foundation model, trained on extensive neural data from many volunteers. Consumer usability is a major focus, with an emphasis on comfort, ease of use, and out-of-the-box functionality.

Spinal cord injury (SCI) often causes long-term disability. But effective means to promote proper regeneration after SCI has so far failed to reach the clinic. Here, we report that fibrotic scar formation at injury sites prevents recovery after SCI and that the inhibition of fibrotic scar formation significantly improved SCI recovery in adult mice. We found that after SCI there is an elevation of macrophages, which are a primary source of activated transforming growth factor-β 1 (TGF-β1) that in turn recruits mesenchymal stromal/stem cells (MSCs) to induce their fibroblast differentiation, thus promoting scar formation.

Implantable silicon neural probes with integrated optical emitters and electrodes are emerging tools for simultaneous optogenetic stimulation and electrophysiological recording in deep brain regions. In parallel, neural probes with microfluidic channels have been developed for localized drug delivery and neurochemical sampling. However, thus far, such fluidic probes have lacked optical and electrical functionalities or been limited to a low number of optical emitters and/or electrodes, constraining their utility in multimodal investigations of neural circuits. Here, we introduce foundry-fabricated silicon nanophotonic neural probes with monolithically integrated microfluidics. Each probe has 16 silicon nitride grating coupler emitters, 18 titanium nitride microelectrodes, and one embedded microfluidic channel.

China is placing high importance on Brain-Computer Interface (BCI) technology, officially included in the 2026 government work report, with Chongqing advancing it from research and development (R&D) to clinical trials and showing early signs of practical success. On March 26, at the Second Affiliated Hospital of Chongqing Medical University, Mr. Wang (pseudonym), a patient recovering from stroke sequelae, underwent rehabilitation training using BCI technology under medical supervision. Powered by brainwaves and wearable devices, Wang was able to move his limbs without exerting active physical effort.

STROKE IS ONE of the leading causes of long-term disability, with roughly two-thirds of survivors experiencing significant impairments in their hands and arms. While some people eventually regain that function, many live with persistent paralysis or weakness. Epia Neuro, a newly launched startup out of San Francisco, wants to help more stroke patients regain hand function with a brain implant and motorized glove.

Stent implantation is widely used to treat coronary artery disease, yet in-stent restenosis (ISR) remains a major clinical challenge. Fractional flow reserve (FFR) is the gold-standard index for evaluating restenosis severity, but current techniques are invasive and unsuitable for continuous monitoring. Here, we present a bioresorbable smart stent platform that enables real-time intravascular pressure sensing and continuous FFR monitoring. The system integrates a MEMS-based LC pressure sensor, fabricated from SU-8 and gold, onto a hybrid 3D-printed vascular stent composed of polycaprolactone (PCL) and polylactic acid (PLA). Structural refinements and an optimized fabrication process enable long-term sensor reliability, minimize signal drift, and maintain stable resonance frequency. Across 100 fabricated devices, the pressure sensors show a resonance frequency of 82.2 ± 1.7 MHz and a sensitivity of 37.48 ± 2.13 kHz/mmHg. In vitro closed-loop fluidic tests using a vascular phantom confirmed the stable, wireless operation of the device and its ability to accurately assess hemodynamic parameters. The dual-sensor configuration enables simultaneous upstream and downstream pressure measurements, yielding FFR values that closely match those from a commercial system (R² = 0.97) under varying stenosis severities. The proposed smart stent offers a promising pathway toward long-term, non-invasive vascular monitoring and early detection of ISR.

The g.GAMMAcap is optimized for use with g.LADYbird TMS electrodes, providing both comfort and quick mounting. Its flexible yet durable fabric includes 74 labeled standard positions (based on the extended 10-20 system) and 86 additional intermediate positions for easy electrode placement. Designed for various experiments like EPs and high-density brain mapping, it allows seamless integration with g.LADYbird electrodes. The cap includes options for a chest belt or chin straps, ensuring a secure fit during recordings.

If stroke, multiple sclerosis or traumatic brain injury affect the ability to move, it isn’t necessarily lost! For that reason, g.tec medical engineering developed recoveriX Neurotechnology, a unique rehabilita­tive approach based on brain-computer interface technology that helps the brain rewire itself.While giving the task to imagine a hand or foot movement, recoveriX provides feedback in real-time through muscle sti­mu­lation and visual simulation. This process induces neuro­pla­sti­city within the brain to relearn hand, arm and foot movements.

The Synchron Stentrode system, known for its novel utilization of MEMS technology and success in a clinical trial enabling computer communication for patients [1], has inspired the development of another technology using a braided stent as a base embedded with insulated DFT wires. Each DFT wire carries a tiny electrode (Fig. 1A left), and the stent connects via a transvascular lead to an external device (Apollo I 32-channel signal acquisition system or in-house recording/stimulation unit). The study aims: 1) to assess the stent-electrode's deliverability, release, and extraction at the transverse sinus (TS) and superior sagittal sinus (SSS); 2) to evaluate signal quality collected by the new system.

In this study, a novel approach is demonstrated for fabricating endovascular micro-wire stent electrodes using laser welding and ablation technologies. The method significantly reduces the electrode size, making it suitable for narrower blood vessels. The quantitative results highlight the excellent electrochemical performance of the electrodes fabricated under optimal laser welding parameters, with a 1 kHz impedance of 4117 Ω, a 1 kHz phase of −68.23 degrees, a charge storage capacity (CSC) of 8.745 (mC/cm2), and a charge injection capacity (CIC) of 1.617 ×10−4C/cm2. These results indicate that the electrodes possess excellent stability and suitability for use as neural interfaces in confined vascular environments.