High-volume post-dilution hemodiafiltration (HVHDF) demonstrates superior preservation of residual kidney function compared to conventional hemodialysis through enhanced hemodynamic stability. This advanced renal replacement therapy technique reduces microinflammatory responses and minimizes nephrotoxic insults to remaining functional nephrons. By maintaining more stable blood pressure and reducing hemodynamic stress, HVHDF creates a less hostile environment for residual renal tissue. The improved convective clearance mechanism of HVHDF also contributes to better removal of uremic toxins and inflammatory mediators. These advantages position HVHDF as a clinically significant option for dialysis patients seeking to extend residual kidney function longevity and potentially improve long-term patient outcomes and quality of life.

This retrospective cohort study examines nutrient density-based dietary indicators in peritoneal dialysis patients, analyzing 794 adults followed for a median of 47 months. Researchers assessed dietary phosphorus, protein, and energy intake using 3-day dietary records collected six months after dialysis initiation, calculating phosphorus-protein, phosphorus-energy, and protein-energy ratios as exposure indicators. The study employed Cox proportional hazards and Fine-Gray competing risk models to evaluate associations with all-cause and cardiovascular mortality. Results demonstrated that the phosphorus-protein ratio exhibited a significant nonlinear association with all-cause mortality among the 412 deaths recorded, including 158 cardiovascular events. Higher phosphorus-protein ratio quintiles compared to the second quintile showed increased mortality risk. These findings suggest that nutrient density-based indicators may provide superior prognostic value compared to absolute nutrient intake for optimizing nutritional management in peritoneal dialysis patients.

Incremental peritoneal dialysis represents an evolving approach to renal replacement therapy that optimizes treatment protocols by gradually increasing dialysate volumes and treatment frequency according to individual patient needs. This comprehensive review examines the historical development of incremental peritoneal dialysis, analyzes its current clinical applications and outcomes, and explores emerging innovations shaping its future. The methodology allows for personalized treatment strategies that may improve patient tolerance, preserve residual kidney function, and enhance quality of life. As nephrology advances, incremental peritoneal dialysis continues to demonstrate significant potential in expanding therapeutic options for end-stage renal disease management, offering promising benefits for diverse patient populations requiring renal replacement therapy.

The Centers for Disease Control and Prevention provides clinical guidance for preventing Clostridioides difficile infection in acute care facilities. The recommendations emphasize isolating patients with suspected or confirmed CDI and implementing contact precautions, including placement in single-patient rooms with dedicated toilets. Healthcare providers should establish nurse-driven protocols for rapid patient isolation and maintain rigorous hand hygiene practices. Additional prevention measures include using dedicated patient-care equipment, performing daily patient bathing with soap and water, and conducting thorough environmental cleaning. The guidance urges facilities to develop comprehensive infrastructure supporting CDI prevention and engage antibiotic stewardship programs. These evidence-based interventions are intended for state and local health departments, hospitals, quality improvement organizations, and other healthcare facilities seeking to reduce CDI transmission and improve patient safety outcomes.

Fresenius Medical Care will participate in the 63rd European Renal Association Congress, scheduled for June 3–6, 2026, in Glasgow, Scotland. This premier nephrology event convenes global medical professionals under the theme "Open Your Mind" and encompasses seven scientific tracks addressing chronic kidney disease, dialysis, transplantation, and related specialties. The congress represents a significant platform for Fresenius Medical Care to showcase innovations, engage with the international nephrology community, and contribute to advancing clinical knowledge and best practices in renal care management.

Renal Research Novum at Karolinska Institutet, led by Dr. Bengt Lindholm, is a specialized research unit focusing on chronic kidney disease, kidney failure, and associated complications including cardiovascular disease, metabolic disorders, and inflammation. The group conducts integrated translational research bridging academia, industry, and clinical practice, with particular emphasis on dialysis therapies and peritoneal dialysis treatment. Comprising ten to fifteen international postdoctoral researchers, the unit maintains robust publication output of approximately twenty original papers and ten review articles annually while actively participating in international conferences. Since its establishment in 1995, the research group has established itself as a leading center for renal medicine investigation and innovation.

This research program investigates how physical forces and molecular mechanisms collaborate to regulate biological processes in cells and tissues. Scientists develop innovative technologies to measure and manipulate physical properties governing cell and tissue behavior, including growth, movement, invasion, and remodeling. By integrating physical measurements with molecular perturbations and computational modeling, the team explores fundamental principles underlying chemical and physical cue interactions in living tissues. Their work examines these principles in physiological and developmental contexts while investigating their dysfunction in cancer and aging. Key research focuses include measuring cellular forces at interfaces, understanding tumor invasion through stromal cell interactions—particularly between cancer cells and fibroblasts—and employing optogenetic technologies for precise mechanical control at subcellular resolution.

Kidney organoids represent a significant advancement in renal research, functioning as three-dimensional in vitro models that faithfully replicate human kidney structure and function. This comprehensive review examines current technologies for kidney organoid generation and their applications in disease research, drug screening, and personalized therapeutic evaluation. Key developments include vascularization strategies, integration with bioprinting and organ-on-chip platforms, immune microenvironment simulation, and improved long-term culture techniques. The article addresses critical translation challenges including large-scale production, data reproducibility, and regulatory considerations. Emerging convergence with precision medicine, microfluidic systems, and biosensing technologies promises substantial clinical impact. Kidney organoids are positioned to revolutionize nephrology research and accelerate the development of innovative therapeutic solutions for renal diseases.

Peritoneal dialysis represents an alternative renal replacement therapy for kidney failure patients, utilizing the peritoneum as a semi-permeable membrane to filter waste and excess fluids. This home-based treatment offers significant advantages including greater flexibility, independence in scheduling, and the ability to perform more frequent treatments, which promotes better fluid and waste management. Patients also benefit from reduced dietary restrictions and enhanced mobility for travel. However, the treatment requires dedicated daily care routines, comprehensive patient education, and close clinical monitoring to ensure safety and efficacy. Success depends heavily on patient commitment and caregiver involvement in maintaining consistent treatment protocols.

Chronic disease represents a significant public health challenge in rural America, imposing substantial burdens on both healthcare systems and residents through diminished quality of life, elevated mortality rates, and rising treatment costs. Rural communities face considerable disadvantages compared to urban counterparts, including limited resources for disease prevention and management, coupled with disproportionately higher prevalence of multiple concurrent chronic conditions that prove difficult and expensive to treat. Key conditions affecting rural populations include heart disease, stroke, type 2 diabetes, chronic respiratory diseases, HIV/AIDS, arthritis, and obesity. This comprehensive guide examines chronic disease's impact on rural America and provides healthcare providers and community organizations with evidence-based strategies, implementation resources, and funding opportunities to establish effective disease management programs and improve health outcomes in underserved rural populations.

Home dialysis modalities offer significant advantages for patients seeking to maintain employment while undergoing treatment. Unlike in-center hemodialysis, which presents substantial physical and mental challenges and limited scheduling flexibility, home dialysis and peritoneal dialysis enable higher employment rates among incident dialysis patients. Current data demonstrates that full-time employment rates are notably higher for home hemodialysis patients at 14.9% compared to 8.5% for in-center dialysis patients. Healthcare providers are increasingly required to evaluate patients' employment goals and status as part of comprehensive psychosocial assessments. By facilitating access to work-compatible dialysis options, nephrologists and social workers can help patients preserve income, health benefits, and personal dignity while managing their chronic kidney disease.

This real-world cohort study, conducted in a public healthcare system in Southern Italy from 2018 to 2025, evaluates the feasibility and impact of telemedicine-supported assisted home hemodialysis for elderly and multimorbid patients. With an average age of 79 years, the study examined 146 patients to assess whether this innovative approach could expand access to home dialysis among traditionally underserved populations with complex medical needs. The research analyzed treatment retention, vascular access patterns, dialysis prescription effectiveness, and economic outcomes related to transportation. A structured telemedicine platform enabling real-time remote monitoring and audiovisual supervision was integrated in September 2023. The findings demonstrate that telemedicine-assisted home hemodialysis represents a viable alternative to conventional in-center dialysis, potentially addressing sustainability and equity challenges within publicly funded healthcare systems while accommodating functionally dependent elderly patients.

This study delves into the efficacy of the CloudCath system, designed to monitor turbidity in dialysis effluent and promptly alert users to potential peritonitis-related changes. The investigation, a single-arm, open-label, multicenter study, involved 243 participants utilizing the CloudCath system during peritoneal dialysis. System notifications were intentionally deactivated for participants and investigators who adhered to the standard of care for peritonitis signs and symptoms. The study’s effectiveness endpoints focused on assessing the time lapse between CloudCath system notifications and peritonitis events, employing the criteria established by the International Society of Peritoneal Dialysis (ISPD).

Patients with end-stage renal disease undergoing haemodialysis experience a variety of stressors leading to decreased level of quality of life (QoL). Thus, in this study, we aimed to review the current literature and identify factors affecting the health-related QoL (HRQoL) in these patients.

Dialysis serves as a substitute for the natural function of the kidneys in individuals with kidney failure. The process involves removing waste and excess fluids from the blood, and maintaining a balance of electrolytes. Top nephrologist in Haryana explains types of dialysis and the factors that are needed to look upon for deciding the type of dialysis one needs. There are following types of dialysis:

While mean platelet volume (MPV) is linked to severity and all-cause mortality in patients with sepsis, its association with all-cause mortality and cardiovascular mortality in patients treated with peritoneal dialysis (PD) remains unknown.

Several studies have demonstrated the efficacy and user acceptance of telehealth in managing patients with chronic conditions, including continuous ambulatory peritoneal dialysis (CAPD). However, the rates of telehealth service use in various patient groups have been low and have declined over time, which may affect important health outcomes. Telehealth service use in patients undergoing CAPD has been recognized as a key challenge that needs to be examined further.

Elevated SII level was independently associated with increased risks of all-cause and CVD mortalities in patients undergoing PD, especially for those younger than 65-year-old. Application of the SII in clinical practice in predicting mortality for patients undergoing PD requires further multicenter prospective studies.

Peritoneal dialysis (PD) as an AKI treatment in adults was widely accepted in critical care settings well into the 1980s. The advent of extracorporeal continuous KRT led to widespread decline in the use of PD for AKI across high-income countries. The lack of familiarity and comfort with the use of PD in critical care settings has also led to lack of use even among those receiving maintenance PD. Many critical care units reflexively convert patients receiving maintenance PD to alternative dialysis therapies at admission. Renewed interest in the use of PD for AKI therapy has emerged due to its increasing use in low- and middle-income countries.

The implementations of telemonitoring systems that reached the highest level of technological maturity correspond to studies developed with the use of proprietary devices and services of international companies specialized in telemedicine treatment of CKD with some limitations regarding their status as proprietary systems incompatible with other devices or systems. Their main limitation is that they are oriented only to treating patients in the APD modality, which limits the care of patients undergoing the CAPD modality. The level of technological maturity is highly relevant for telemonitoring systems. Therefore, this work can serve as a reference point for researchers and technologists focused on developing telemonitoring systems for patients with CKD undergoing PD. Future work will extend to analyzing the level of technological maturity of cyber–physical systems aimed at telemonitoring CKD patients undergoing PD.